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Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community, medical students, and the medical industry. We will post a workweek daily medical or surgical term, its meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Thomas Willis, MD
Thomas Willis
(1621-1675)

An English physician and anatomist, Willis was born on his parents' farm in Great Bedwyn, Wiltshire, where his father held the stewardship of the Manor. He was a kinsman of the Willys baronets of Fen Ditton, Cambridgeshire. He graduated M.A. from Christ Church, Oxford in 1642. In the Civil War years he was a royalist, and was dispossessed of the family farm at North Hinksey by Parliamentary forces. In the 1640's Willis was one of the royal physicians to Charles I of England. He obtained his medical degree in 1646.

Thomas Willis might well be one of the greatest physicians of the 17th century.He is one of the founders of the Royal Society of London. He is remembered by his many publications, especially "Cerebri Anatome: Cui accessit Nervorum Descriptio et Usu", where he describes the arterial anastomoses at the base of the brain. This work is also the first detailed description of the vasculature of the brain. Willis described nine cranial nerves.

He is considered as the father of Neurology as a discipline. He used the term "neurology" for the first time in 1664. He described several neurological conditions

The Arterial Circle of Willis is a famous eponymous structure found at the base of the brain. It represents an anastomotic roundabout that connects the right and left sides as well as the carotid and vertebral arterial territories that supply the brain. Named after Thomas Willis, this structure was known well before him, but it was Willis who described its function.  If you click on the image or here, you will be redirected to a detailed description of this structure.

Sources:

1. "The legendary contributions of Thomas Willis (1621-1675): the arterial circle and beyond" Rengachary SS et al J Neurosurg. 2008 Oct;109(4):765-75
2. "Thomas Willis, a pioneer in translational research in anatomy (on the 350th anniversary of Cerebri anatome)" Arraez-AybarJournal of Anatomy, 03/2015, Volume 226, Issue 3
3. " The naming of the cranial nerves: A historical review" Davis, M Clinical Anatomy, 01/2014, Volume 27, Issue 1
4. "Observations on the history of the circle of Willis". Meyer A, Hieros, R.Med Hist 6:119–130, 1962


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Mondino de Luzzi


This article is part of the series "A Moment in History" where we honor those who have contributed to the growth of medical knowledge in the areas of anatomy, medicine, surgery, and medical research.To search all the articles in this series, click here.
Mondino de Luzzi (ca.1270 – 1326). Italian anatomist, born Raimondo de Luzzi in the city of Bologna circa 1270.  He was also known as Mondino, Remondino, or Mundinus de Leutiis, de Lentiis, de Lucci, and other variations of his name. His father Nerino Franzoli was an apothecary, and Mondino also started working as such.

In 1290 he enrolled in the Medical School at the University of Bologna obtaining his medical degree circa 1290. Mondino stayed at the university, where he continued to teach until his death in 1326.

His major publication is “Anothomia Corporis Humani”, written circa 1316 and found only in manuscript form. It was finally printed in movable type in 1478, making it easily available to the public. While some authors like Singer, 1925 contend that this is his only publication, others discuss the possibility that Mondino de’ Luzzi wrote other books that have been adjudicated to other authors as at the time the name “Mondino” was very common.

“Anothomia Corporis Humani” is the first anatomical book based on actual dissections, and the book was organized almost as a dissection manual, explaining dissection techniques to visualize specific structures. Initially this book had no illustrations, but some were added in later publications.

Title page of Anathomia Corporis Humanis by Mondino de Luzzi. Image courtesy of the National Library of Medicine
Title page of Anathomia Corporis Humanis by Mondino de Luzzi
With over 40 editions, the last one in 1668, this book was used for almost 250 years. Mondino restarted human dissections in medical schools almost 1,500 years the medical school of Alexandria, leading many to call Mondino the “restorer of anatomy”.

It is said that Leonardo da Vinci (1452 – 1519) used one of Mondino’s books as a dissection manual to guide his own. Because Mondino followed Galen’s dictums and teachings, he was harshly criticized for his errors by Andreas Vesalius (1514 – 1564).

Although it is not clear if Mondino himself performed the actual dissections (he says he did), it is clear that he directed them. We know of two of his assistants:  Otto Agenio Lustrolanus and Alessandra Giliani, the first woman prosector and anatomist. When Mondino died the same year as Alessandra Giliani, the expectation was that his assistant would continue the work of the master. Sadly Otto Agenio Lustrolanus died before he was 30 years old.

In the introduction to “Anothomia” Mondino says: "A work upon any science or art-as saith Galen-is issued for three reasons: First, that one may satisfy his friends. Second, that he may exercise his best mental powers. Third, that he may be saved from the oblivion incident to old age. Therefore, moved by these three causes, I have proposed to my pupils to compose a certain work on Medicine.”

"And because a knowledge of the parts to be subjected to medicine (which is the human body, and the names of its various divisions) is a part of medical science, as saith Averrhoes in his first chapter, in the section on the definition of medicine, for this reason among others I have set out to lay before you the knowledge of the parts of the human body which is derived from anatomy, not attempting to use a lofty style, but the rather that which is suitable to a manual procedure."

Sources:
1. “Mondino de' Luzzi's commentary on the Canones Generales of Mesue the Younger” Welborn, MC. Isis  , 22: 1 (1934) , 8-11
2. “Medieval neuroanatomy: the text of Mondino dei Luzzi and the plates of Guido da Vigevano” Orly R. J Hist Neurosci. 1997 6 (2):113-123
3. “Mondino de Luzzi (1270-1326) Restaurador de la Disecci?n Anat?mica” Rever?n, RR. Informe Medico 2007; 9 (12):589-592
4. “The history and illustration of anatomy in the Middle Ages” Gurunluoglu, R, et al. J Med Biogr 2013 21: 219 – 229
5. “The Mondino Myth” Pilcher, LS. 1906
Original image courtesy of NLM