Medical Terminology Daily - Est. 2012

Medical Terminology Daily (MTD) is a blog sponsored by Clinical Anatomy Associates, Inc. as a service to the medical community. We post anatomical, medical or surgical terms, their meaning and usage, as well as biographical notes on anatomists, surgeons, and researchers through the ages. Be warned that some of the images used depict human anatomical specimens.

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A Moment in History

Georg Eduard Von Rindfleisch

Georg Eduard Von Rindfleisch
(1836 – 1908)

German pathologist and histologist of Bavarian nobility ancestry. Rindfleisch studied medicine in Würzburg, Berlin, and Heidelberg, earning his MD in 1859 with the thesis “De Vasorum Genesi” (on the generation of vessels) under the tutelage of Rudolf Virchow (1821 - 1902). He then continued as a assistant to Virchow in a newly founded institute in Berlin. He then moved to Breslau in 1861 as an assistant to Rudolf Heidenhain (1834–1897), becoming a professor of pathological anatomy. In 1865 he became full professor in Bonn and in 1874 in Würzburg, where a new pathological institute was built according to his design (completed in 1878), where he worked until his retirement in 1906.

He was the first to describe the inflammatory background of multiple sclerosis in 1863, when he noted that demyelinated lesions have in their center small vessels that are surrounded by a leukocyte inflammatory infiltrate.

After extensive investigations, he suspected an infectious origin of tuberculosis - even before Robert Koch's detection of the tuberculosis bacillus in 1892. Rindfleisch 's special achievement is the description of the morphologically conspicuous macrophages in typhoid inflammation. His distinction between myocardial infarction and myocarditis in 1890 is also of lasting importance.

Associated eponyms

"Rindfleisch's folds": Usually a single semilunar fold of the serous surface of the pericardium around the origin of the aorta. Also known as the plica semilunaris aortæ.

"Rindfleisch's cells": Historical (and obsolete) name for eosinophilic leukocytes.

Personal note: G. Rindfleisch’s book “Traité D' Histologie Pathologique” 2nd edition (1873) is now part of my library. This book was translated from German to French by Dr. Frédéric Gross (1844-1927) , Associate Professor of the Medicine Faculty in Nancy, France. The book is dedicated to Dr. Theodore Billroth (1829-1894), an important surgeon whose pioneering work on subtotal gastrectomies paved the way for today’s robotic bariatric surgery. Dr. Miranda.

Sources:
1. "Stedmans Medical Eponyms" Forbis, P.; Bartolucci, SL; 1998 Williams and Wilkins
2. "Rindfleisch, Georg Eduard von (bayerischer Adel?)" Deutsche Biographie
3. "The pathology of multiple sclerosis and its evolution" Lassmann H. (1999)  Philos Trans R Soc Lond B Biol Sci. 354 (1390): 1635–40.
4. “Traité D' Histologie Pathologique” G.E.
Rindfleisch 2nd Ed (1873) Ballieres et Fils. Paris, Translated by F Gross


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The medical term embolus arises from the Greek [έμβολο] (pronounced émvolo) meaning "a plug", or "a plunger". This Greek term was later adopted in Latin [embolus] and is used in this unchanged form today. The plural for embolus is [emboli].

In medicine, the term embolus usually refers to a free blood clot that travels down the bloodstream. When in the veins, emboli will travel easily to and through the heart. This is because veins increase in diameter towards the heart. The opposite happens in arteries. Free blood clots (emboli) that passed through the heart with no problem now enter the pulmonary arteries whose branches get smaller and smaller until the emboli plug the arterioles, and now the patient has a pulmonary embolism.

When thrombi are generated in the heart, they are usually generated in the left atrial appendage in cases of arrhythmia or atrial fibrillation.  If these thrombi embolize, that is, they become free, these now emboli will continue downstream in the arteries and progressively smaller arterioles until they are bigger that the vessel and plug it, cutting off blood supply. This condition can cause an infarction, also known as a stroke. 

The term embolus can also refer to liquids. fat, or gases that enter the blood stream and are not diluted. 

The first use of this term in modern medicine was by Virchow in 1846 in his paper "On the Occlusion of the Pulmonary Arteries"

The root term for this word is [-embol-]. Examples of its use are:

Embolism:  The suffix [-ism] means "behavior" or "pathology".
• Thromboembolism: A combination of root terms; the root term  [-thromb-] means "fixed clot" and [-embol] means "a free clot". A condition or presence of both trombi and emboli.

Sources:
1. "The Origin of Medical Terms" Skinner, HA 1970 Hafner Publishing Co.
2. "Medical Meanings - A Glossary of Word Origins" Haubrich, WD. ACP Philadelphia